Related Experiment Video
Updated: Oct 15, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
An overview of pruritus in autoimmune connective tissue diseases
1Department of Dermatology, Venereology and Leprology, All India Institute of Medical Sciences, Jodhpur, India.
Abstract:
Autoimmune connective tissue diseases (ACTD) are a broad spectrum of diseases including dermatomyositis, systemic lupus erythematosus, Sjogren syndrome, systemic sclerosis, and mixed connective tissue diseases. Pruritus is an unpleasant sensation leading to scratching. It is most commonly seen in dermatomyositis patients among ACTD. Itch can be mild to severe, hampering daily activities. It is often associated with disease severity. Apart from ACTD, pruritus may be due to antimalarial agents or due to adverse effects of medications used in ACTD. Therefore, it is prudent to find the pathogenesis of pruritus for adequate treatment. Pruritus in ACTD is underreported and undertreated. The article gives a comprehensive view of pruritus in ACTD, its pathogenesis, and management.
Related Concept Videos
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune...
Introduction to Connective Tissues
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Connective Tissue Cell Types
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...

