Related Experiment Video
Updated: Oct 15, 2025
07:11
Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
Published on: July 19, 2018
15.6K
Prescribing Home Hemodialysis.
Joel D Glickman1, Isaac Teitelbaum2, Thomas A Golper3
1Section on Renal Disease and Hypertension, Perlman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Advances in Chronic Kidney Disease
|October 31, 2021
Summary
Home hemodialysis (HHD) is gaining popularity due to user-friendly equipment like the NxStage system. This article explains the Frequent Low Dialysate Volume Approach (FLDVA) for effective urea removal at home.
Area of Science:
- Nephrology
- Biomedical Engineering
Background:
- Home hemodialysis (HHD) is underutilized but experiencing a resurgence.
- Innovative, user-friendly dialysis equipment drives HHD's comeback.
- NxStage systems dominate the current HHD market.
Purpose of the Study:
- To explain the Frequent Low Dialysate Volume Approach (FLDVA) used by the NxStage platform.
- To detail methods for increasing dialysate saturation for efficient urea removal.
- To provide a model for estimating and adjusting HHD prescriptions.
Main Methods:
- Focus on the NxStage platform and its FLDVA.
- Explanation of techniques to enhance dialysate saturation.
- Comparison of urea removal dynamics between peritoneal dialysis and NxStage therapy.
Main Results:
- The NxStage platform minimizes dialysate volume per treatment.
- High dialysate saturation is crucial for achieving target urea removal with reduced volumes.
- A model is presented for HHD prescription management.
Conclusions:
- Understanding dialysate saturation is key to optimizing HHD with the NxStage system.
- FLDVA enables effective urea removal in home settings.
- The study provides a framework for HHD prescription adjustments.
Related Concept Videos
01:24Hemodialysis II: Procedure and Complications
189
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
189
01:25Hemodialysis I: Introduction
420
Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
420
01:25Hemodialysis III: Nursing Management
287
The nursing management of a patient undergoing hemodialysis includes several critical steps, starting with a thorough assessment before the procedure.Before the Hemodialysis ProcedureFirst, record the patient's vital signs—blood pressure, heart rate, respiratory rate, and temperature—to establish a baseline. This baseline is essential for detecting conditions such as hypotension that could impact the patient's response to dialysis. Document the patient's pre-dialysis weight, as this...
287
01:27Dialysis
625
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
625
01:30Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis
29
Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
29
01:25Peritoneal Dialysis III: Nursing Management
205
Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
205