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The UCSC Genome Browser database: 2022 update
Brian T Lee1, Galt P Barber1, Anna Benet-Pagès1,2
1Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Nucleic Acids Research
|October 31, 2021
Summary
The UCSC Genome Browser offers enhanced tools for exploring genomic data, including new clinical tracks and SARS-CoV-2 genome analysis. This update improves visualization, comparison, and interpretation of genetic information for researchers.
Area of Science:
- Genomics
- Bioinformatics
- Computational Biology
Background:
- The UCSC Genome Browser is a key resource for visualizing and analyzing genomic data.
- Continuous updates are necessary to incorporate new datasets and improve analytical capabilities.
Purpose of the Study:
- To present the latest updates and features of the UCSC Genome Browser.
- To enhance the analysis of genomic and clinical data, including SARS-CoV-2.
- To improve user experience and data accessibility.
Main Methods:
- Integration of new public hub assemblies and clinical tracks (e.g., gnomAD, DECIPHER).
- Development of a new Track Sets feature and enhanced variant displays.
- Implementation of a phylogenetic tree tool for SARS-CoV-2 genome analysis.
- Usability enhancements including improved mouseover displays and fonts.
Main Results:
- Expanded organism coverage with accessible public hub assemblies.
- Improved interpretation of clinical data through enhanced variant displays and new features.
- Facilitated rapid phylogenetic analysis of emerging SARS-CoV-2 mutations.
- Enhanced user interface and data visualization tools.
Conclusions:
- The updated UCSC Genome Browser provides powerful new tools for genomic research.
- Enhanced clinical data interpretation and SARS-CoV-2 analysis are now available.
- The platform continues to evolve as a vital resource for the scientific community.
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