Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomics02:02

Genomics

38.0K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
38.0K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

19.5K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
19.5K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

6.4K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.4K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

14.7K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.7K
CRISPR/Cas9 Genome Editing01:28

CRISPR/Cas9 Genome Editing

625
The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
625
CRISPR and crRNAs02:53

CRISPR and crRNAs

17.8K
Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
17.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Servo-Actuated 3D-Printed Disposable Microvalves for Automated, Scalable Organoid Culture in Standard Incubators.

bioRxiv : the preprint server for biology·2026
Same author

Cloud-connected pluripotent stem cell platform enhances scientific identity in underrepresented students.

Stem cell reports·2026
Same author

SpikeLab: Agentic tools for spike data analysis.

bioRxiv : the preprint server for biology·2026
Same author

Microfluidic Control of Dorsal-Ventral Patterning Within a Single Forebrain Organoid.

bioRxiv : the preprint server for biology·2026
Same author

The diploid reference genome of a human embryonic stem cell line.

bioRxiv : the preprint server for biology·2026
Same author

Evaluating genome assemblies with HMM-Flagger.

bioRxiv : the preprint server for biology·2026
Same journal

Correction to 'New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress'.

Nucleic acids research·2026
Same journal

VeloRM: disentangling pre- and post-splicing RNA modification dynamics at single-cell resolution.

Nucleic acids research·2026
Same journal

Accessibility of telomeric overhangs to stabilizing small-molecule ligands.

Nucleic acids research·2026
Same journal

Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex.

Nucleic acids research·2026
Same journal

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites.

Nucleic acids research·2026
Same journal

Correction to 'The Gene Ontology knowledgebase in 2026'.

Nucleic acids research·2026
See all related articles

Related Experiment Video

Updated: Oct 15, 2025

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

3.6K

The UCSC Genome Browser database: 2022 update.

Brian T Lee1, Galt P Barber1, Anna Benet-Pagès1,2

  • 1Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.

Nucleic Acids Research
|October 31, 2021
PubMed
Summary
This summary is machine-generated.

The UCSC Genome Browser offers enhanced tools for exploring genomic data, including new clinical tracks and SARS-CoV-2 genome analysis. This update improves visualization, comparison, and interpretation of genetic information for researchers.

More Related Videos

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

9.4K
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

10.0K

Related Experiment Videos

Last Updated: Oct 15, 2025

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

3.6K
A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

9.4K
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

10.0K

Area of Science:

  • Genomics
  • Bioinformatics
  • Computational Biology

Background:

  • The UCSC Genome Browser is a key resource for visualizing and analyzing genomic data.
  • Continuous updates are necessary to incorporate new datasets and improve analytical capabilities.

Purpose of the Study:

  • To present the latest updates and features of the UCSC Genome Browser.
  • To enhance the analysis of genomic and clinical data, including SARS-CoV-2.
  • To improve user experience and data accessibility.

Main Methods:

  • Integration of new public hub assemblies and clinical tracks (e.g., gnomAD, DECIPHER).
  • Development of a new Track Sets feature and enhanced variant displays.
  • Implementation of a phylogenetic tree tool for SARS-CoV-2 genome analysis.
  • Usability enhancements including improved mouseover displays and fonts.

Main Results:

  • Expanded organism coverage with accessible public hub assemblies.
  • Improved interpretation of clinical data through enhanced variant displays and new features.
  • Facilitated rapid phylogenetic analysis of emerging SARS-CoV-2 mutations.
  • Enhanced user interface and data visualization tools.

Conclusions:

  • The updated UCSC Genome Browser provides powerful new tools for genomic research.
  • Enhanced clinical data interpretation and SARS-CoV-2 analysis are now available.
  • The platform continues to evolve as a vital resource for the scientific community.