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Bupropion-Associated Delayed Onset Urticaria.

Nikolas Gutierrez1, Sara Malik2, Philip R Cohen3

  • 1General Practice, 1st Marine Division, 1st Combat Engineer Battalion, Camp Pendleton, USA.

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|November 1, 2021
PubMed
Summary
This summary is machine-generated.

Bupropion, an antidepressant, can rarely cause delayed urticaria. This case highlights the importance of recognizing this atypical hypersensitivity reaction to bupropion for accurate diagnosis and management.

Keywords:
adverseantidepressantbupropiondelayeddrug eruptionhypersensitivity pruritisskinurticaria

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Area of Science:

  • Pharmacology
  • Dermatology
  • Clinical Medicine

Background:

  • Bupropion is a widely prescribed oral antidepressant.
  • Its mechanism involves norepinephrine and dopamine reuptake inhibition.
  • Generally well-tolerated with mild side effects, but rare hypersensitivity reactions like urticaria can occur.

Observation:

  • A 20-year-old male developed severe, pruritic urticaria after three weeks of bupropion treatment.
  • The rash presented as erythematous wheals on the abdomen, flanks, and upper extremities.
  • This reaction exhibited a delayed onset and atypical presentation.

Findings:

  • The case illustrates a rare instance of delayed onset bupropion-associated urticaria.
  • Misdiagnosis is a potential issue due to the condition's atypical clinical features.
  • This adverse reaction highlights the need for increased awareness among clinicians.

Implications:

  • Accurate identification of bupropion-induced urticaria is crucial for patient management.
  • Further research may be needed to understand the prevalence and pathophysiology of delayed hypersensitivity.
  • Clinicians should consider bupropion as a potential cause for new-onset urticaria, even with delayed presentation.