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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Related Experiment Video

Updated: Aug 23, 2025

Establishment of a Clinic-based Biorepository
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Cutaneous Basal Cell Carcinoma In Situ: A Case Series.

Philip R Cohen1

  • 1Dermatology, University of California, Davis Medical Center, Sacramento, USA.

Cureus
|October 27, 2022
PubMed
Summary
This summary is machine-generated.

Basal cell carcinoma in situ (BCCis) is a non-invasive skin cancer confined to the epidermis. This condition can be effectively treated with surgical excision or topical imiquimod cream, showing no recurrence.

Keywords:
basal cell carcinomabasal cell carcinoma in situcancercutaneousin situmelanomamelanoma in situskinsquamous cell carcinomasquamous cell carcinoma in situ

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Basal cell carcinoma (BCC) is a common skin cancer, with subtypes ranging from non-invasive to invasive.
  • Carcinoma in situ refers to malignancies confined to the epidermis, lacking dermal invasion.

Observation:

  • This case series describes three men with basal cell carcinoma in situ (BCCis) presenting as superficial, erythematous plaques on the trunk.
  • Tumors were morphologically characterized as red, scaly or non-scaly plaques.

Findings:

  • BCCis exhibited characteristic clinical and microscopic findings, including epidermal replacement by basaloid cells without dermal invasion.
  • All three cases achieved successful treatment without recurrence using surgical excision or topical 5% imiquimod cream.

Implications:

  • BCCis is a distinct clinicopathologic entity, previously often classified as superficial BCC.
  • Effective treatment options exist for BCCis due to its epidermal confinement, but vigilance is needed for mixed histology to prevent recurrence.