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Related Experiment Video

Updated: Oct 14, 2025

Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy

Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy

Published on: April 17, 2020

Hemodynamic management in brain dead donors.

Chiara Lazzeri¹, Manuela Bonizzoli², Cristiana Guetti²

¹Intensive Care Unit and Regional ECMO Referral Centre, Azienda Ospedaliero Universitaria Careggi, Florence 50134, Italy. lazzeri.ch@gmail.com.

World Journal of Transplantation

|November 1, 2021

Summary

This summary is machine-generated.

Effective hemodynamic management in brain death donors (DBD) is crucial for organ retrieval. This review highlights optimal vasoactive and hormonal therapies, and monitoring strategies for marginal donors to improve organ transplantation outcomes.

Keywords:

Brain-dead donors Echocardiography Hemodynamic Hormanal therapy Management Vasoactive drugs

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Last Updated: Oct 14, 2025

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Published on: August 15, 2022

Area of Science:

Organ transplantation
Critical care medicine
Nephrology

Background:

Hemodynamic instability in brain death donors (DBD) leads to significant organ loss.
Limited evidence exists for managing hemodynamic instability in DBDs, especially marginal donors (older, comorbid).
Evolving donor demographics necessitate updated management guidelines.

Purpose of the Study:

To summarize evidence on hemodynamic management strategies for DBDs, focusing on vasoactive drugs and monitoring.
To review therapeutic approaches for elderly DBDs.
To provide guidance for optimizing organ retrieval and transplantation.

Main Methods:

Systematic review of available evidence on hemodynamic management in DBDs.
Focus on vasoactive drug therapies and monitoring parameters.
Inclusion of data on elderly DBD management.

Main Results:

Norepinephrine is the primary vasoactive agent globally; vasopressin is recommended for higher doses.
Hormonal therapy (desmopressin, corticosteroids, thyroid hormone) is advised for all DBDs.
Monitoring, including echocardiography, is key to achieving therapeutic goals.

Conclusions:

Optimized donor management is critical for maximizing organ retrieval and transplantation success.
Tailored therapeutic regimens, considering organ type, are essential.
Adherence to specific monitoring and therapeutic goals improves donor outcomes.