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Updated: Oct 14, 2025

Author Spotlight: Mitochondrial Remodeling in Skeletal Muscle
Published on: December 1, 2023
Subcellular Specialization of Mitochondrial Form and Function in Skeletal Muscle Cells
T Bradley Willingham1, Peter T Ajayi1, Brian Glancy1,2
1National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States.
Abstract:
Across different cell types and within single cells, mitochondria are heterogeneous in form and function. In skeletal muscle cells, morphologically and functionally distinct subpopulations of mitochondria have been identified, but the mechanisms by which the subcellular specialization of mitochondria contributes to energy homeostasis in working muscles remains unclear. Here, we discuss the current data regarding mitochondrial heterogeneity in skeletal muscle cells and highlight potential new lines of inquiry that have emerged due to advancements in cellular imaging technologies.
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