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Rivaroxaban in acute venous thromboembolism: UK prescribing experience
Victoria Speed1,2, Jignesh P Patel1,2, Derek Cooper3
1Department of Haematological Medicine King's Thrombosis Centre King's College Hospital NHS Foundation Trust London UK.
Research and Practice in Thrombosis and Haemostasis
|November 1, 2021
Summary
Rivaroxaban effectively treated venous thromboembolism (VTE) in UK daily care, showing low recurrence and bleeding rates. Further data is needed for women of childbearing age.
Area of Science:
- Cardiology
- Pharmacology
- Clinical Research
Background:
- Rivaroxaban is a recommended treatment for acute venous thromboembolism (VTE).
- Previous studies like the Einstein program demonstrated its efficacy and safety compared to traditional therapies.
- The drug offers a convenient oral option for VTE management.
Purpose of the Study:
- To evaluate the safety and efficacy of rivaroxaban for acute VTE management in routine UK clinical practice.
- To assess outcomes including recurrent VTE, bleeding events, and all-cause mortality.
Main Methods:
- The FIRST registry was a multicenter, noninterventional, observational study in the UK.
- Consecutive patients with acute VTE treated with rivaroxaban were enrolled and followed for up to 5 years.
- Primary outcomes included recurrent VTE, major and clinically relevant nonmajor bleeding (CRNMB), and all-cause mortality.
Main Results:
- 1262 patients were recruited, exhibiting diverse demographics (age 18-95, weight 35-234 kg, BMI up to 64.4 kg/m²).
- The study observed a low rate of symptomatic VTE recurrence (0.6%) and major or CRNMB (6.4%).
- Abnormal vaginal bleeding was a notable CRNMB in women under 50.
Conclusions:
- Rivaroxaban is a safe and effective monotherapy for treating VTE in UK daily practice.
- Real-world data supports rivaroxaban's role in VTE management.
- More research is required to establish optimal anticoagulation strategies for women of childbearing age.
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