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Updated: Oct 14, 2025

Measurements of Physiological Stress Responses in C. Elegans
Published on: May 21, 2020
The Argonaute Proteins ALG-1 and ALG-2 Are Linked to Stress Resistance and Proteostasis
Fabian Finger1,2,3, Franziska Ottens1,2, Thorsten Hoppe1,2,4
1Institute for Genetics, University of Cologne, 50674 Cologne, Germany.
Abstract:
The conserved Argonaute-family members ALG-1 and ALG-2 are known to regulate processing and maturation of microRNAs to target mRNAs for degradation or translational inhibition (Bouasker and Simard 2012; Meister 2013). Consequently, depletion of alg-1 and alg-2 results in multiple phenotypes. Our data describe a role of microRNA-regulation in stress resistance and proteostasis with special emphasis on ubiquitin-dependent degradation pathways, such as ubiquitin fusion degradation (UFD) and endoplasmic reticulum (ER)-associated protein degradation (ERAD).
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