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Updated: Oct 14, 2025

Manufacture and Drug Delivery Applications of Silk Nanoparticles

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Published on: October 8, 2016

AS1411-functionalized delivery nanosystems for targeted cancer therapy.

Pooria Safarzadeh Kozani¹, Pouya Safarzadeh Kozani^2,3, Mohammad Tariq Malik^4,5

¹Carlos Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 14115/111, Iran.

Exploration of Medicine

|November 1, 2021

Summary

Nucleolin (NCL) is a cancer target, and the AS1411 aptamer binds it effectively. AS1411-functionalized nanosystems offer targeted cancer therapy by delivering agents specifically to tumor cells.

Keywords:

AS1411 Nucleolin aptamer cancer drug delivery nanoparticles

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Area of Science:

Biochemistry
Molecular Biology
Oncology

Background:

Nucleolin (NCL) is a key protein involved in cell proliferation, survival, and growth.
Overexpression and dysregulation of NCL are linked to various cancers, making it a promising therapeutic target.

Purpose of the Study:

To review advances in cancer therapy targeting Nucleolin (NCL) using AS1411-functionalized delivery nanosystems.
To explore the selective delivery of therapeutic agents to tumor cells via NCL targeting.

Main Methods:

AS1411, a DNA aptamer with high affinity for NCL, was utilized.
Nanosystems were functionalized with AS1411 for targeted delivery.
The review explores therapeutic payload delivery to tumor cells.

Main Results:

AS1411 demonstrates high affinity and specificity for NCL.
AS1411 induces growth inhibition in various tumor cells.
AS1411-functionalized nanosystems enable selective targeting of tumor cells.

Conclusions:

AS1411 is a potent NCL-targeting agent for cancer therapy.
Functionalized nanosystems enhance targeted delivery of therapeutics.
This approach holds promise for selective cancer treatment.