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Related Experiment Videos

Unrecognized leukemia cutis.

J D Hainsworth, F A Greco

    Southern Medical Journal
    |May 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    A skin eruption initially misdiagnosed as breast cancer metastasis resolved with tamoxifen. However, this was followed by acute myelomonocytic leukemia, with identical cancer cells found in both the skin and bone marrow.

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    Area of Science:

    • Oncology
    • Dermatology
    • Hematology

    Background:

    • Accurate diagnosis of neoplastic skin infiltrations is crucial for effective cancer treatment.
    • Distinguishing between metastatic carcinoma and other skin conditions can be challenging.

    Observation:

    • A 76-year-old woman with a history of breast cancer presented with a diffuse erythematous maculonodular skin eruption.
    • Initial biopsy suggested metastatic breast carcinoma, and the patient was treated with tamoxifen.
    • Peripheral blood and bone marrow showed no abnormalities at the time of skin lesion presentation.

    Findings:

    • The skin lesions completely resolved over nine months with tamoxifen treatment.
    • Subsequently, the patient developed acute myelomonocytic leukemia.
    • Leukemic blasts in the bone marrow were morphologically identical to the malignant cells identified in the initial skin biopsies.

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    Implications:

    • This case highlights the importance of comprehensive diagnostic evaluation for skin lesions in cancer patients.
    • Cytochemical, immunohistochemical staining, and electron microscopy are valuable tools when light microscopy is inconclusive for diagnosing neoplastic skin infiltrations.
    • Misdiagnosis can lead to delayed or inappropriate treatment, underscoring the need for accurate identification of neoplastic cells in skin.