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The Activin/FLRG Pathway Associates with Poor COVID-19 Outcomes in Hospitalized Patients

Megan McAleavy1, Qian Zhang1, Peter J Ehmann1

  • 1Regeneron Pharmaceuticals Inc., Tarrytown, New York, USA.

Molecular and Cellular Biology
|November 1, 2021
PubMed
Summary

Elevated activin A levels in hospitalized COVID-19 patients correlate with severe disease and mortality. Blocking activin A signaling in a hamster model did not worsen SARS-CoV-2 infection, suggesting potential therapeutic benefits.

Keywords:
ARDSCOVID-19FLRGFSTL3SARS-Cov-2activin Aactivin Bacute respiratory disease syndrome

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