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Related Experiment Video

Updated: Oct 14, 2025

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Improved Sensitivity of Ultrasound-Based Subharmonic Aided Pressure Estimation Using Monodisperse Microbubbles.

Wim van Hoeve1, Miguel de Vargas Serrano1, Lisa Te Winkel1

  • 1Solstice Pharmaceuticals B.V, Enschede, Netherlands.

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
|November 1, 2021
PubMed
Summary
This summary is machine-generated.

Monodisperse microbubbles significantly enhance Subharmonic Aided Pressure Estimation (SHAPE) sensitivity for noninvasive hydrostatic pressure measurement. This advancement nearly doubles the sensitivity compared to current clinical methods.

Keywords:
microfluidicsmonodispersepressure estimationsubharmonicultrasound contrast agents

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Area of Science:

  • Biomedical Engineering
  • Acoustic Imaging
  • Medical Device Technology

Background:

  • Subharmonic Aided Pressure Estimation (SHAPE) is a valuable noninvasive technique for measuring hydrostatic fluid pressures.
  • Current SHAPE methods utilize polydisperse microbubbles, which may limit sensitivity and accuracy.
  • Improving SHAPE sensitivity is crucial for broader clinical applications and enhanced diagnostic capabilities.

Purpose of the Study:

  • To investigate the potential of monodisperse microbubbles to improve SHAPE sensitivity.
  • To characterize the acoustic properties and stability of monodisperse microbubble populations.
  • To evaluate the performance of monodisperse microbubbles in a hydrostatic pressure-controlled environment.

Main Methods:

  • Monodisperse microbubbles were fabricated using microfluidics and characterized for size distribution and stability.
  • Acoustic attenuation and resonance frequencies were measured to determine microbubble properties.
  • SHAPE sensitivity was assessed using a clinical ultrasound scanner in a controlled pressure bath.

Main Results:

  • Successfully created monodisperse microbubble suspensions (2.4–5.3 μm) with stable size distributions over 24 hours.
  • Resonance frequencies correlated strongly with microbubble diameter (R² > 0.99).
  • Monodisperse bubbles exhibited nearly double the SHAPE sensitivity (-0.17 dB/mmHg) compared to commercial polydisperse bubbles.

Conclusions:

  • Monodisperse microbubbles offer a significant improvement in SHAPE sensitivity.
  • This advancement holds promise for more accurate noninvasive hydrostatic pressure measurements.
  • Further development could lead to enhanced diagnostic tools in various clinical settings.