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Updated: Oct 14, 2025

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
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INFLUENCE OF COMPLEX TREATMENT WITH MAGNESIUM AND POTASSIUM SALTS OF GLUCONIC ACID, EPLERENONE AND RIVAROXABAN ON

Igor P Vakaliuk1, Nataliia V Savchuk1, Roksolana V Nesterak1

  • 1IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|November 2, 2021
PubMed

Insights

Rivaroxaban combination therapy improved anti-ischemic effects in heart failure patients post-myocardial infarction. Eplerenone use promoted significant left ventricular remodeling in these patients.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Heart failure (CHF) post-myocardial infarction (MI) requires effective treatment strategies.
  • Stenting is a common intervention for MI patients.

Purpose of the Study:

  • To evaluate the effectiveness of complex therapy including magnesium and potassium gluconate, eplerenone, and rivaroxaban in CHF patients after MI.
  • To compare the efficacy of different therapeutic agents in improving outcomes.

Main Methods:

  • Study conducted at Ivano-Frankivsk Regional Clinical Cardiology Centre, Ukraine.
  • 84 patients diagnosed with CHF after MI were included in the examination.

Main Results:

  • Combination therapy with rivaroxaban demonstrated a more pronounced anti-ischemic effect compared to magnesium and potassium gluconate or eplerenone.
  • Eplerenone use resulted in significant reverse remodeling of the left myocardium in the postinfarction period.

Conclusions:

  • Rivaroxaban-based combination therapy enhances anti-ischemic effects in CHF patients post-MI.
  • Eplerenone is effective in promoting left ventricular reverse remodeling in this patient cohort.
Abstract

Keywords:
eplerenoneheart failurepostinfarction cardiosclerosisremodelingrivaroxabanstenting

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