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Updated: Jul 11, 2025
Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
THE ROLE OF NEUROHORMONAL FACTORS IN THE FORMATION OF A PATIENT'S CLINICAL PROFILE AND THE IMPACT ON STRUCTURAL
Mariana O Vatseba1, Nadiia M Haliuk1, Tetiana V Merhel1
1IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE.
Insights
Galectin-3 levels increase with heart failure after myocardial infarction, correlating with cardiac remodeling. This suggests galectin-3 can help diagnose and predict outcomes in these patients.
Area of Science:
- Cardiology
- Biochemistry
- Medical Diagnostics
Background:
- Myocardial infarction (MI) can lead to chronic heart failure (CHF).
- Cardiac and vascular remodeling are key pathological processes following MI.
- Galectin-3 is a protein implicated in inflammatory and fibrotic processes.
Purpose of the Study:
- To investigate the role of galectin-3 in the clinical profile of patients with MI.
- To assess the impact of galectin-3 on cardiac and vascular remodeling post-MI with reperfusion therapy.
Main Methods:
- Studied 140 patients with CHF post-MI (FC II-III) and 22 patients with MI without CHF.
- Analyzed serum galectin-3 concentrations.
- Correlated galectin-3 levels with left ventricular remodeling indicators (ESV, LVEDV).
Main Results:
- Elevated serum galectin-3 in MI patients with CHF (35.2-38.94 ng/ml) compared to healthy subjects (6.57 ng/ml).
- Significantly higher galectin-3 in patients with stenting without CHF (10.87 ng/ml) vs. healthy.
- Positive correlations found between galectin-3 and left ventricular volumes (ESV, LVEDV).
Conclusions:
- Galectin-3 concentration correlates with left ventricular remodeling in post-MI CHF.
- Galectin-3 serves as a potential marker for early diagnosis, prognosis, and risk stratification in post-MI remodeling.
Objective:
The aim: To determine the dynamics of galectin-3 in the formation of the patient's clinical profile and the impact on structural cardiac and vascular remodeling in patients with myocardial infarction after reperfusion therapy.
Patients And Methods:
Materials and methods: 140 patients with class II A CHF syndrome according to Vasilenko-Strazhesko FC II-III (NYHA), which occurred in patients with MI, and 22 patients with MI without signs of CHF were examined.
Results:
Results: The average serum galectin-3 level of the studied patients was analyzed. The average concentration of galectin-3 in patients with stenting without signs of CHF was (10.87±1.65) ng/ml comparing to (6.57±0.21) ng/ml in healthy subjects (p<0.05). An increase in the concentration of this indicator was observed in the group of patients with CHF after MI with reperfusion - (35.2±1.76) ng/ml, which is significantly higher in comparison with practically healthy subjects, and in patients without revascularization it was (38.94±1.97) ng/ml (p<0.001). Positive correlations of medium strength were found between left ventricular end-systolic volume (ESV), left ventricular end-diastolic volume (LVEDV) and serum galectin-3 concentration in the examined patients. The correlation coefficient between the abovementioned indicators was 0.60 (p<0.01) and 0.53 (p<0.05), respectively.
Conclusion:
Conclusions: It has been determined that in patients with CHF with postinfarction cardiosclerosis there is a direct correlation of medium strength between the values of indicators of LV myocardial remodeling with plasma galectin-3 concentration, including ESV, EDV, in examined patients. The role of galectin-3 as a marker of postinfarction remodeling in patients with CHF for early diagnosis, prognosis, and risk stratification has been presented.
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