Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obesity01:24

Obesity

716
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
716
Microbial Nutrition01:28

Microbial Nutrition

511
Organisms exhibit remarkable metabolic diversity, categorized based on how they acquire energy and carbon. These strategies enable survival in various ecological niches and are essential for maintaining energy flow and nutrient cycling within ecosystems.Energy and Carbon SourcesOrganisms are classified as phototrophs or chemotrophs based on energy acquisition. Phototrophs use light as their energy source, while chemotrophs rely on oxidizing chemical compounds. Further differentiation arises...
511
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

748
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
748
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

14.5K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
14.5K
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

20
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
20
Metabolic States of the Body: Fasting and Starvation01:24

Metabolic States of the Body: Fasting and Starvation

1.9K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcriptomic Analysis in the Liver of Two Rabbit Lines Divergently Selected for Intramuscular Fat Content.

Animal genetics·2026
Same author

Bivariate GWAS performed on rabbits divergently selected for intramuscular fat content reveals pleiotropic genomic regions and genes related to meat and carcass quality traits.

Genetics, selection, evolution : GSE·2025
Same author

Nutritional Composition, Technological Quality, and Sensory Attributes of Chicken Breast Meat Affected by White Striping, Wooden Breast, and Spaghetti Meat: A Comprehensive Evaluation.

Foods (Basel, Switzerland)·2025
Same author

Cecal metabolomics of 2 divergently selected rabbit lines revealed microbial mechanisms correlated to intramuscular fat deposition.

Journal of animal science·2024
Same author

Correlated Responses to Selection for Intramuscular Fat on the Gut Microbiome in Rabbits.

Animals : an open access journal from MDPI·2024
Same author

Process understanding and monitoring: A glimpse into data strategies for miniaturized NIR spectrometers.

Analytica chimica acta·2024

Related Experiment Video

Updated: Oct 14, 2025

Compost Microcosms as Microbially Diverse, Natural-like Environments for Microbiome Research in Caenorhabditis elegans
07:19

Compost Microcosms as Microbially Diverse, Natural-like Environments for Microbiome Research in Caenorhabditis elegans

Published on: September 13, 2022

2.4K

Comprehensive functional core microbiome comparison in genetically obese and lean hosts under the same environment.

Marina Martínez-Álvaro1, Agostina Zubiri-Gaitán2, Pilar Hernández2

  • 1Scotland´s Rural College, Edinburgh, UK. marina.alvaro@sruc.ac.uk.

Communications Biology
|November 2, 2021
PubMed
Summary
This summary is machine-generated.

Host genetics significantly alter gut microbiome functions related to lipid metabolism in rabbits. This research identifies specific microbial genes influencing intramuscular fat deposition, offering insights for obesity management strategies.

More Related Videos

Divergence of Root Microbiota in Different Habitats based on Weighted Correlation Networks
09:49

Divergence of Root Microbiota in Different Habitats based on Weighted Correlation Networks

Published on: September 25, 2021

4.5K
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

30.3K

Related Experiment Videos

Last Updated: Oct 14, 2025

Compost Microcosms as Microbially Diverse, Natural-like Environments for Microbiome Research in Caenorhabditis elegans
07:19

Compost Microcosms as Microbially Diverse, Natural-like Environments for Microbiome Research in Caenorhabditis elegans

Published on: September 13, 2022

2.4K
Divergence of Root Microbiota in Different Habitats based on Weighted Correlation Networks
09:49

Divergence of Root Microbiota in Different Habitats based on Weighted Correlation Networks

Published on: September 25, 2021

4.5K
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

30.3K

Area of Science:

  • Animal Genetics
  • Microbiome Research
  • Metabolic Disease

Background:

  • Intramuscular fat deposition is a key economic trait in livestock.
  • Host genetics play a crucial role in shaping the gut microbiome.
  • Understanding the interplay between host genetics and the microbiome is vital for metabolic health.

Purpose of the Study:

  • To comprehensively compare gut microbiome core functionalities between rabbit lines divergently selected for intramuscular lipid deposition.
  • To identify specific microbial genes and pathways influenced by host genetic selection for fat accretion.

Main Methods:

  • Divergent selection for intramuscular fat over 10 generations in rabbits.
  • Analysis of 3,936 microbial gene abundances in the cecum.
  • Application of compositional and multivariate statistical techniques.

Main Results:

  • Identified 122 cecum microbial genes with differential abundances between selected rabbit lines.
  • Demonstrated host genetic influence on microbial biosynthesis of lipopolysaccharides, peptidoglycans, lipoproteins, mucin components, and NADH reductases.
  • Differentiated host-genetically influenced microbial mechanisms regulating lipid deposition in body versus intramuscular reservoirs (28 commonly contributing genes).

Conclusions:

  • Host genetic determination for lipid accretion significantly impacts gut microbiome composition and function.
  • Specific microbial genes are implicated in regulating lipid deposition, with distinct mechanisms for body and muscle fat.
  • Findings provide a basis for developing microbiome-targeted strategies to combat obesity.