Antimicrobial activity of imipenem and SCH34343 against Legionella species

Twenty-seven Legionella spp. strains were tested against four beta-lactams, erythromycin and rifampin by a buffered ACES-yeast extract broth microdilution method. The minimum concentrations inhibiting 90% of strains were imipenem 0.06 micrograms/ml, SCH34343 0.25 micrograms/ml, amoxicillin 0.5 micrograms/ml, cefotaxime less than or equal to 0.12 micrograms/ml, erythromycin 0.25 micrograms/ml, and rifampin less than or equal to 0.008 micrograms/ml.