Related Experiment Video
Updated: Oct 14, 2025

Three-Dimensional Shape Modeling and Analysis of Brain Structures
Published on: November 14, 2019
Shape-changing chains for morphometric analysis of 2D and 3D, open or closed outlines
Bingjue Li1, Shengmin Zhou2, Andrew Peter Murray3
1School of Mechanical Engineering and Jiangsu Key Laboratory for Design and Manufacture of Micro/Nano Biomedical Instruments, School of Mechanical Engineering, Southeast University, Nanjing, 211189, Jiangsu, China. libj@seu.edu.cn.
This study introduces a novel shape-changing chain method for morphometrics, simplifying complex shape analysis. This technique offers a more interpretable and efficient approach for biological and medical shape studies.
Area of Science:
- Morphometrics
- Geometric Morphometrics
- Shape Analysis
Background:
- Traditional morphometrics often involves numerous variables, complicating analysis and interpretation, especially for complex shapes or large datasets.
- Existing methods can be difficult to apply to diverse 2D or 3D profiles and may yield results lacking clear physical meaning.
Purpose of the Study:
- To present a new methodology for synthesizing shape-changing chains for 2D/3D curve fitting.
- To utilize shape-changing chain parameters in stepwise discriminant analysis (DA).
Main Methods:
- Developed a shape-changing chain model with rigid, scalable, and extendible segments.
- Applied the chain fitting to 2D profiles (fossil hominin mandibles, leaf outlines) and 3D curves (infant skull sutures).
- Used stepwise discriminant analysis (DA) on the derived chain parameters.
Main Results:
- The shape-changing chain method successfully analyzed diverse 2D and 3D profiles, including open/closed and smooth/serrated curves.
- Segmentation is flexible, automatic, and incorporates biological/geometric features.
- The method yields a modest number of variables for statistical analysis with physically meaningful parameters.
Conclusions:
- The shape-changing chain offers advantages over common morphometric techniques, providing a flexible, efficient, and interpretable approach to shape analysis.
- This method is broadly applicable across various biological, medical, and paleoanthropological datasets.
Related Concept Videos
Newman Projections
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as...
Molecular Shapes
Two regions of electron density in a diatomic...
Deformations in a Transverse Cross Section
As the material stretches, it expands or contracts in orthogonal directions to the load. This phenomenon varies...
Conformations of Cyclohexane
The chair form is the most stable and derives its name from its resemblance to the “easy chair.” In the chair conformation, two carbon atoms are arranged out-of-plane — one above and one below, minimizing the torsional strain. In the chair form, the bond angle is very close to the ideal...
Fischer Projections
Streamlines, Streaklines, and Pathlines

