Related Experiment Video

Updated: Oct 14, 2025

Lung Tumor Cell Recruitment Assay
04:28

Lung Tumor Cell Recruitment Assay

Published on: February 26, 2019

5.5K

uPAR: An Essential Factor for Tumor Development

Tao Lv1,2, Ying Zhao1, Xinni Jiang3

  • 1College of Biological Resource and Food Engineering, Qujing Normal University, Qujing, Yunnan, China 655011.

Journal of Cancer
|November 3, 2021
PubMed

Insights

Urokinase-type plasminogen activator receptor (uPAR) plays a key role in tumor progression. Understanding uPAR

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Tumorigenesis involves the dysregulation of numerous genes.
  • Urokinase-type plasminogen activator receptor (uPAR) is a cell surface protein implicated in cancer.
  • uPAR expression is elevated in various tumor tissues.

Purpose of the Study:

  • To review the regulatory roles of the uPAR signaling pathway in tumor progression.
  • To explore uPAR's influence on key cancer processes.
  • To highlight uPAR's potential as a biomarker for therapeutic efficacy.

Main Methods:

  • Literature review of studies on uPAR signaling in cancer.
  • Analysis of uPAR's involvement in tumor cell proliferation, adhesion, and metastasis.
  • Examination of uPAR's role in glycolysis, tumor microenvironment, and angiogenesis.

Main Results:

  • uPAR signaling significantly impacts tumor cell proliferation, adhesion, and metastasis.
  • uPAR influences metabolic reprogramming through glycolysis.
  • uPAR affects the tumor microenvironment and angiogenesis, crucial for tumor growth.
  • uPAR induction correlates with tumor progression and impacts therapeutic outcomes.

Conclusions:

  • uPAR is a critical factor in multiple facets of tumor progression.
  • uPAR's role in tumorigenesis suggests its importance in predicting therapeutic response.
  • Further research into uPAR-coreceptor interactions is vital for cancer diagnostics and treatment strategies.
Keywords:
adhesioncancer therapymetastasisproliferationtumorigenesisuPAR

More Related Videos

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

335
Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo08:19

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

6.1K

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.7K
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
50.7K
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.6K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.4K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.0K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K