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Updated: Oct 14, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
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Recent developments in the medicinal chemistry of single boron atom-containing compounds

Shu Song1, Ping Gao1, Lin Sun1

  • 1Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012, China.

Acta Pharmaceutica Sinica. B
|November 3, 2021
PubMed
Abstract

Keywords:
ACTs, artemisinin combination therapiesADCs, Acinetobacter-derived cephalosporinasesAML, acute myeloid leukemiaAMT, aminopterinBLs, β-lactamasesBNCT, boron neutron capture therapyBNNPs, boron nitride nanoparticlesBNNTs, boron nitride nanotubesBoron-containing compoundsCEs, carboxylesterasesCIA, collagen-induced arthritisCOVID-19, coronavirus disease 2019ClpP, casein protease PCovalent inhibitorsGSH, glutathioneHADC1, class I histone deacetylaseHBV, hepatitis B virusHCV, hepatitis C virusHIV, human immunodeficiency virusLeuRS, leucyl-tRNA synthetaseLinker componentsMBLs, metal β-lactamasesMDR-TB, multidrug-resistant tuberculosisMERS, Middle East respiratory syndromeMIDA, N-methyliminodiacetic acidMM, multiple myelomaMTX, methotrexateMcl-1, myeloid cell leukemia 1Mtb, Mycobacterium tuberculosisNA, neuraminidaseNS5B, non-nucleoside polymeraseOBORT, oxaborole tRNA captureOPs, organophosphatePBA, phenylboronic acidPDB, Protein Data BankPPI, protein–protein interactionProdrugQM, quinone methideRA, rheumatoid arthritisROS, reactive oxygen speciesSARS-CoV-2, syndrome coronavirus 2SBLs, serine β-lactamasesSERD, selective estrogen receptor downregulatorSHA, salicyl hydroxamic acidSaClpP, Staphylococcus aureus caseinolytic protease PTB, tuberculosisTTR, transthyretinU4CR, Ugi 4-component reactioncUTI, complex urinary tract infectiondCTPase, dCTPase pyrophosphatase

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