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Prothrombotic state in patients with stable COPD: an observational study
Christos Kyriakopoulos1, Christos Chronis1, Evaggelia Papapetrou2
1Respiratory Medicine Dept, University Hospital of Ioannina, Ioannina, Greece.
ERJ Open Research
|November 3, 2021
Summary
Patients with stable chronic obstructive pulmonary disease (COPD) show a prothrombotic state, with higher coagulation factors and lower inhibitors like protein S and antithrombin. Disease severity correlates with these coagulation changes.
Area of Science:
- Pulmonary Medicine
- Hematology
- Cardiovascular Medicine
Background:
- Chronic obstructive pulmonary disease (COPD) is linked to increased risks of cardiovascular disease and venous thromboembolism.
- Understanding the prothrombotic state in COPD is crucial for managing these comorbidities.
Purpose of the Study:
- To investigate the prothrombotic state in patients with stable COPD.
- To compare coagulation parameters between COPD patients and COPD-free smokers.
Main Methods:
- An observational study comparing coagulation markers in stable COPD patients and control subjects.
- Measured D-dimers, INR, aPTT, coagulation factors (fibrinogen, FII, FV, FVII, FVIII, FIX, FX), and inhibitors (protein S, protein C, antithrombin).
Main Results:
- COPD patients exhibited higher D-dimers, fibrinogen, FII, FV, FVIII, and FX compared to controls.
- COPD patients showed lower levels of protein S and antithrombin.
- More severe COPD was associated with higher FII, FV, FX, and lower protein S levels.
Conclusions:
- Stable COPD patients present a prothrombotic profile with elevated coagulation factors and reduced inhibitors.
- Disease severity in COPD correlates with specific alterations in coagulation factors and protein S levels.
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