Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

1.5K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.5K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

3.0K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.0K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

3.3K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.3K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

3.1K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.1K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

2.6K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.6K
Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

182
Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
182

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization of CT Imaging-Derived Pulmonary Vascular Abnormalities Associated With Pulmonary Hypertension in Chronic Lung Disease.

Chest·2026
Same author

Measures of vascular volume in the lung: an emerging quantitative tool for clinical and physiological studies in pulmonary vascular disease.

American journal of respiratory cell and molecular biology·2026
Same author

The clinical relevance of chest computed tomography imaging in pulmonary hypertension associated with lung diseases.

Current opinion in pulmonary medicine·2026
Same author

Increased Venous Volumes in Response to Catheter-Based Intervention for Acute PE: Lessons From the OPTALYSE PE Trial (OPTALYSE-3D).

Circulation. Cardiovascular imaging·2026
Same author

Optimizing the Accuracy of Natural Language Processing Tools for Pulmonary Embolism Detection Through Integration with Claims Data: The PE-EHR+ Study.

Thrombosis and haemostasis·2026
Same author

Pulmonary vascular features on chest computed tomography differentially associate with adverse outcomes in smokers in COPDGene.

Annals of the American Thoracic Society·2025
Same journal

The epidemiological burden and societal cost of 14 respiratory conditions in the World Health Organization European region: systematic evidence map and economic analysis.

ERJ open research·2026
Same journal

Menthol inhalation relieves dyspnoea through the brain.

ERJ open research·2026
Same journal

Understanding the perceptions and experiences of adults with early-onset neuromuscular disorders using noninvasive ventilation in making healthcare decisions.

ERJ open research·2026
Same journal

Exploring glucocorticoid receptor signalling in lymphangioleiomyomatosis.

ERJ open research·2026
Same journal

Senescence intensifies bleomycin-induced injury in idiopathic pulmonary fibrosis lung epithelial cells.

ERJ open research·2026
Same journal

Absolute and relative intensity of physical activity after lung cancer surgery.

ERJ open research·2026
See all related articles

Related Experiment Video

Updated: Oct 14, 2025

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD
04:03

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

Published on: September 27, 2024

942

Hypercoagulation in COPD: the clot thickens.

Farbod N Rahaghi1, Carrie L Pistenmaa1

  • 1Pulmonary and Critical Care, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

ERJ Open Research
|November 3, 2021
PubMed
Summary
This summary is machine-generated.

Stable chronic obstructive pulmonary disease (COPD) is linked to hypercoagulability, affecting multiple blood clotting factors. This condition is not solely due to inflammation or thrombosis causes.

More Related Videos

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
04:53

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

986
Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
09:22

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

Published on: November 4, 2015

12.3K

Related Experiment Videos

Last Updated: Oct 14, 2025

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD
04:03

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

Published on: September 27, 2024

942
Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
04:53

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

986
Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
09:22

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

Published on: November 4, 2015

12.3K

Area of Science:

  • Pulmonary Medicine
  • Hematology
  • Thrombosis Research

Background:

  • Chronic obstructive pulmonary disease (COPD) is a progressive lung condition.
  • Emerging evidence suggests a link between stable COPD and hypercoagulability.
  • Hypercoagulability involves alterations in the blood's clotting system.

Discussion:

  • The study investigates the presence and nature of hypercoagulability in stable COPD patients.
  • It examines changes in various coagulation factors contributing to this state.
  • The findings differentiate COPD-associated hypercoagulability from that caused by general inflammation or thrombosis.

Key Insights:

  • Stable COPD is characterized by a hypercoagulable state.
  • Multiple coagulation factors are implicated in COPD-related hypercoagulability.
  • This hypercoagulability is an intrinsic feature, not merely a consequence of inflammation.

Outlook:

  • Further research is needed to understand the precise mechanisms.
  • Investigating therapeutic strategies targeting hypercoagulability in COPD is warranted.
  • This understanding may lead to improved patient outcomes and reduced thrombotic risk.