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Updated: Oct 14, 2025

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Published on: December 6, 2021
Emerging Single-Atom Catalysts/Nanozymes for Catalytic Biomedical Applications
Zihao Wang1, Fu-Gen Wu1,2,3
1State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, 2 Sipailou Road, Nanjing, 210096, P. R. China.
Single-atom catalysts (SACs) offer high atom utilization and catalytic activity. This review details SAC synthesis, characterization, and applications in nanomedicine, addressing aggregation challenges for improved biomedical uses.
Area of Science:
- Materials Science
- Nanotechnology
- Catalysis
Background:
- Single-atom catalysts (SACs) are atomically dispersed nanozymes with high atom utilization.
- They exhibit excellent catalytic activity and selectivity, with broad applications in environmental, energy, and chemical fields.
- However, single atoms tend to aggregate, reducing catalytic efficiency.
Purpose of the Study:
- To review synthetic methods and characterization techniques for SACs.
- To summarize the application of SACs in nanomedicine.
- To outline current challenges and future opportunities for SACs in nanomedicine.
Main Methods:
- Literature review of synthesis and characterization of SACs.
- Compilation of application cases in nanomedicine.
- Analysis of challenges and future prospects.
Main Results:
- SACs offer superior catalytic performance due to isolated active sites.
- Substrate interactions are crucial for preventing single-atom aggregation.
- SACs show significant potential in various nanomedicine applications.
Conclusions:
- Effective strategies are needed to stabilize single atoms and prevent aggregation.
- Further research into SACs can lead to advanced nanomedicine solutions.
- Developing SACs with enhanced properties will broaden their biomedical applications.
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