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Updated: Oct 14, 2025

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
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Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

Published on: March 20, 2014

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Palladium-catalyzed post-Ugi arylative dearomatization/Michael addition cascade towards plicamine analogues

Chao Liu1, Ruiqi Zhao1, Liangliang Song2

  • 1Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, KU Leuven Celestijnenlaan 200F, 3001, Leuven, Belgium. erik.vandereycken@kuleuven.be.

Organic & Biomolecular Chemistry
|November 3, 2021
PubMed
Summary

A novel palladium-catalyzed reaction efficiently creates diverse plicamine analogues from Ugi-adducts. This method combines Ugi-4CR and dearomatization for rapid, step-economical synthesis of complex molecules.

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