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Related Experiment Video

Updated: Oct 14, 2025

Author Spotlight: Advancing Syphilis Research — Innovations in Treponema pallidum Cultivation and Genetic Engineering
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[Syphilis, the forgotten disease].

Petra Tunbäck1

  • 1överläkare, docent, Verksamhet hud- och könssjukvård, Sahlgrenska universitetssjukhuset, Göteborg; vice ordf, sektionen för venereologi inom SSDV (Svenska sällskapet för dermatologi och venereologi).

Lakartidningen
|November 3, 2021
PubMed
Summary

Syphilis rates declined with HIV awareness but are now rising globally. While uncommon in Sweden, syphilis can be asymptomatic or cause ulcers, rash, or neurosyphilis, and congenital transmission remains a concern.

Area of Science:

  • Infectious Diseases
  • Public Health
  • Epidemiology

Background:

  • Syphilis incidence decreased in the late 20th century, influenced by HIV awareness.
  • A resurgence of syphilis is now observed globally.
  • Sweden reports a lower incidence (4.6/100,000) compared to other STIs like chlamydia and gonorrhea.

Purpose of the Study:

  • To review the current status of syphilis, including its varied clinical manifestations and the persistent issue of congenital transmission.
  • To emphasize the importance of maternal care and timely treatment for preventing congenital syphilis.

Main Methods:

  • Literature review and epidemiological data analysis.
  • Clinical case descriptions and public health surveillance data.

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Main Results:

  • Syphilis presents with diverse symptoms, including asymptomatic infection, genital ulcers, rash, fever, and neurosyphilis.
  • Congenital syphilis remains a significant global health problem.
  • Effective maternal care and treatment are crucial for preventing fetal transmission.

Conclusions:

  • Despite past declines, syphilis requires ongoing surveillance and intervention due to its resurgence and potential for severe outcomes.
  • Preventing congenital syphilis necessitates universal access to prenatal care and prompt syphilis treatment for pregnant individuals.