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Updated: Oct 14, 2025

Identification, Isolation, and Characterization of Fibro-Adipogenic Progenitors FAPs and Myogenic Progenitors MPs in Skeletal Muscle in the Rat
Published on: June 9, 2021
Diabetes-induced skeletal muscle fibrosis: Fibro-adipogenic precursors at work
Bénédicte Chazaud1, Rémi Mounier1
1Institut NeuroMyoGène, UMR CNRS 5310 - Inserm U1217, Université Claude Bernard Lyon 1, Université Lyon, Lyon, France.
Abstract:
Skeletal muscle fibrosis is a complication of diabetes and insulin resistance. In this issue of Cell Metabolism, Farup et al. (2021) characterized fibro-adipogenic precursors (FAPs) in human skeletal muscle and showed that a CD34+CD90+ FAP subset is involved in diabetes-induced muscle fibrosis through PDGFRα signaling and activation of glycolysis.
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