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Related Experiment Video

Updated: Oct 14, 2025

Author Spotlight: Advancements and Challenges in Machine Perfusion for Liver Transplantation

Author Spotlight: Advancements and Challenges in Machine Perfusion for Liver Transplantation

Published on: June 14, 2024

EMPEROR-Preserved: A promise fulfilled.

Deepak L Bhatt¹, Subodh Verma², Bertram Pitt³

¹Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Cell Metabolism

|November 3, 2021

Summary

Empagliflozin significantly reduced heart failure hospitalizations and cardiovascular death in patients with heart failure with preserved ejection fraction (HFpEF). This SGLT2 inhibitor offers a breakthrough treatment for this challenging cardiovascular condition.

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Area of Science:

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Background:

Heart failure with preserved ejection fraction (HFpEF) is a major clinical challenge with limited treatment options.
HFpEF affects a significant portion of heart failure patients, contributing to high morbidity and mortality.

Purpose of the Study:

To evaluate the efficacy of empagliflozin in reducing cardiovascular events in patients with HFpEF.

Main Methods:

The study involved patients diagnosed with HFpEF.
Empagliflozin, an SGLT2 inhibitor, was administered to assess its impact on key outcomes.

Main Results:

Empagliflozin demonstrated a 21% reduction in the composite outcome of heart failure hospitalizations and cardiovascular death.
These findings were reported in the New England Journal of Medicine (NEJM).

Conclusions:

Empagliflozin represents a significant therapeutic advancement for patients with HFpEF.
This study marks a breakthrough in managing heart failure with preserved ejection fraction.