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EMPEROR-Preserved: A promise fulfilled

Deepak L Bhatt1, Subodh Verma2, Bertram Pitt3

  • 1Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Cell Metabolism
|November 3, 2021
PubMed

Insights

Empagliflozin significantly reduced heart failure hospitalizations and cardiovascular death in patients with heart failure with preserved ejection fraction (HFpEF). This SGLT2 inhibitor offers a breakthrough treatment for this challenging cardiovascular condition.

Area of Science:

  • Cardiology
  • Endocrinology

Background:

  • Heart failure with preserved ejection fraction (HFpEF) is a major clinical challenge with limited treatment options.
  • HFpEF affects a significant portion of heart failure patients, contributing to high morbidity and mortality.

Purpose of the Study:

  • To evaluate the efficacy of empagliflozin in reducing cardiovascular events in patients with HFpEF.

Main Methods:

  • The study involved patients diagnosed with HFpEF.
  • Empagliflozin, an SGLT2 inhibitor, was administered to assess its impact on key outcomes.

Main Results:

  • Empagliflozin demonstrated a 21% reduction in the composite outcome of heart failure hospitalizations and cardiovascular death.
  • These findings were reported in the New England Journal of Medicine (NEJM).

Conclusions:

  • Empagliflozin represents a significant therapeutic advancement for patients with HFpEF.
  • This study marks a breakthrough in managing heart failure with preserved ejection fraction.

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