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Association of TIMP-2 Rs8179090 Genotypes With Lung Cancer Risk in Taiwan

Wei-Chih Liao1,2, Chien-Wen Huang3, Te-Chun Hsia1,4

  • 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, R.O.C.

Anticancer Research
|November 4, 2021
PubMed
Abstract

Insights

The tissue inhibitor of metalloproteinase-2 (TIMP-2) -418G/C gene variant does not appear to influence lung cancer risk. This genetic variation is unlikely to be a reliable predictor for developing lung cancer.

Area of Science:

  • Genetics and Genomics
  • Cancer Biology
  • Molecular Medicine

Background:

  • The tissue inhibitor of metalloproteinase-2 (TIMP-2) is a key regulator of extracellular matrix (ECM) degradation and remodeling.
  • TIMP-2, alongside matrix metalloproteinases (MMPs), plays a crucial role in maintaining tissue homeostasis.
  • Dysregulation of ECM remodeling is implicated in various diseases, including cancer.

Purpose of the Study:

  • To investigate the association between the TIMP-2 -418G/C single nucleotide polymorphism (SNP) and the risk of developing lung cancer.
  • To determine if specific genotypes of the TIMP-2 -418G/C polymorphism are linked to lung cancer susceptibility.

Main Methods:

  • A case-control study was conducted with 358 lung cancer patients and 716 healthy controls.
  • Genotyping for the TIMP-2 -418G/C (rs8179090) polymorphism was performed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.

Main Results:

  • No statistically significant differences were observed in the distribution of TIMP-2 -418G/C allele and genotype frequencies between lung cancer patients and healthy controls (p>0.05).
  • The frequencies of heterozygous and homozygous variant genotypes of TIMP-2 -418G/C did not differ significantly between the case and control groups (p>0.05).

Conclusions:

  • The studied TIMP-2 -418G/C genetic variants are unlikely to be associated with lung cancer susceptibility.
  • These specific TIMP-2 gene variants may not serve as effective predictive biomarkers for lung cancer risk.
Keywords:
GenotypeTIMP-2Taiwanlung cancerpolymorphism

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