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Published on: September 27, 2018
Pathogenicity of the MAGE family
Sanyan Li1, Xiang Shi1, Jingping Li2
1Department of Pathology, Qianjiang Central Hospital, Qianjiang, Hubei 433100, P.R. China.
Abstract:
The melanoma antigen gene (MAGE) protein family is a group of highly conserved proteins that share a common homology domain. Under normal circumstances, numerous MAGE proteins are only expressed in reproduction-related tissues; however, abnormal expression levels are observed in a variety of tumor tissues. The MAGE family consists of type I and II proteins, several of which are cancer-testis antigens that are highly expressed in cancer and serve a critical role in tumorigenesis. Therefore, this review will use the relationship between MAGEs and tumors as a starting point, focusing on the latest developments regarding the function of MAGEs as oncogenes, and preliminarily reveal their possible mechanisms.
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