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Updated: Oct 14, 2025

Experimental Human Pneumococcal Carriage
Published on: February 15, 2013
An initiative to improve pneumococcal immunization counseling in children with nephrotic syndrome
Ibrahim Sandokji1,2, Linda S Anderson3, Jillian K Warejko3
1Department of Pediatrics, Section of Nephrology, Clinical and Translational Research Accelerator, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520-8064, USA. isandokji@gmail.com.
Insights
Children with nephrotic syndrome need pneumococcal polysaccharide vaccine (PPSV23) to prevent infections. Quality improvement efforts significantly increased PPSV23 counseling rates from 12% to 86% through provider education and EHR reminders.
Area of Science:
- Pediatric Nephrology
- Immunology
- Public Health
Background:
- Pneumococcal infections pose a severe risk to children with nephrotic syndrome.
- The 23-valent pneumococcal polysaccharide vaccine (PPSV23) is crucial for this patient group.
- Current guidelines are not consistently followed, leading to under-vaccination.
Purpose of the Study:
- To improve the rate of PPSV23 counseling in children with nephrotic syndrome.
- To achieve a counseling rate exceeding 70% within 12 months.
- To identify effective interventions for increasing vaccine adherence.
Main Methods:
- A quality improvement project was implemented in a nephrology clinic.
- Interventions included enhancing provider awareness, improving communication, and increasing adherence.
- Data was collected via electronic health records (EHR) and tracked using control charts.
Main Results:
- Adherence to PPSV23 counseling increased from a baseline of 12% to 86%.
- Provider awareness and EHR reminders were key effective interventions.
- Sustained adherence was observed throughout the project duration.
Conclusions:
- Addressing provider knowledge gaps and utilizing EHR reminders are effective strategies.
- These interventions can improve PPSV23 counseling adherence in children with nephrotic syndrome.
- The approach may be applicable to other immunocompromised pediatric populations requiring specific vaccinations.
Background:
Immunization is essential in preventing life-threatening pneumococcal infections in children with nephrotic syndrome. An additional 23-valent pneumococcal polysaccharide vaccine (PPSV23) series is required for children with nephrotic syndrome. Despite current practice guidelines, many children with nephrotic syndrome do not receive PPSV23.
Methods:
Our nephrology clinic conducted a quality improvement project to improve the overall rate of PPSV23 counseling to more than 70% within a 12-month period by applying several targeted interventions to raise providers' awareness, improve communication with primary care providers, and increase provider adherence. Data was collected from the electronic health record (EHR), and monthly performance was tracked via monthly control charts and overall immunization counseling rate charts.
Results:
We increased adherence to PPSV23 vaccination counseling from a baseline of 12 to 86%. The first intervention that effectively increased the vaccine counseling rate from 12 to 30% was improving a provider's awareness of the PPSV23 literature and vaccine guidelines. Other interventions included regular performance reviews at division meetings, creating an immunization protocol, posting performance charts on the office bulletin board, and unifying vaccine recommendation templates. Lastly, specific and timely EHR reminders improved the total counseling rate from 52 to 86% and maintained adherence until the completion of the project.
Conclusion:
Bridging the knowledge gap in provider awareness and using specific EHR reminders can improve adherence to PPSV23 counseling in children with nephrotic syndrome. Such interventions could be applied to similar groups of immunocompromised patients in whom additional vaccines are indicated. A higher resolution version of the Graphical abstract is available as Supplementary information.
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