Dynamic nano-assemblies based on two-dimensional inorganic nanoparticles: Construction and preclinical demonstration
Luyao Sun1, Jingjing Wang1, Li Li1
1Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.
Advanced Drug Delivery Reviews
|November 5, 2021
Summary
Intelligent dynamic drug delivery systems (DDSs) using 2D nanomaterials can transform in response to disease environments or external triggers. This review explores their engineering, applications, and challenges for effective medical treatments.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Dynamic drug delivery systems (DDSs) offer controllable drug release.
- Two-dimensional (2D) inorganic nanomaterials are suitable for advanced DDS development due to their properties.
Purpose of the Study:
- To review engineering methods for creating transformable 2D DDSs.
- To discuss dynamic inorganic 2D DDSs responsive to biological and external stimuli.
- To address challenges in clinical translation and safety assessment.
Main Methods:
- Engineering methodologies: composition changes, defect creation, surface modification (polymers, biomolecules, nanodots).
- Stimuli-responsive mechanisms: tumor microenvironment (pH, redox, hypoxia, enzymes) and external triggers (light, magnetism, ultrasound).
Main Results:
- Demonstrated various engineering approaches for 2D DDSs.
- Highlighted DDS transformation driven by disease-specific and external stimuli.
- Identified key challenges for clinical application and in vivo safety.
Conclusions:
- Transformable 2D inorganic DDSs show great promise for targeted therapy.
- Further research is needed to overcome limitations for clinical translation.
- In vivo safety assessment is crucial for future development.
Keywords:
Disassembly and reassemblyDynamic drug delivery systemsStimuli-driven theranosticSurface functionalizationTransformable 2D inorganic nanomaterialsTumor microenvironment
