Aggregation-induced emission (AIE)-guided dynamic assembly for disease imaging and therapy

Area of Science:

• Supramolecular Chemistry
• Materials Science
• Biomedical Engineering

Background:

• Aggregation-induced emission (AIE) is intrinsically linked to molecular aggregation and self-assembly.
• The synergy between AIE and supramolecular self-assembly presents a promising avenue for advanced applications.

Purpose of the Study:

• To review recent advancements in AIE-guided dynamic assembly (AGDA).
• To explore AGDA's constructing strategies, stimuli-responsive imaging capabilities, and intramolecular motion regulation for disease diagnosis and therapy.

Main Methods:

• Review of literature on AGDA construction and applications.
• Analysis of AIE molecule behavior under various stimuli.
• Examination of dynamic assembly mechanisms in response to endogenous and exogenous triggers.

Main Results:

• AGDA effectively responds to diverse stimuli in the disease microenvironment (pH, enzymes, temperature, light, etc.).
• AGDA enables specific imaging and diagnosis of disease lesions.
• AGDA can dynamically adjust intramolecular motion for switching between photodynamic and photothermal therapies.

Conclusions:

• AGDA represents a powerful strategy for developing smart diagnostic and therapeutic systems.
• Understanding AGDA's response mechanisms is crucial for optimizing its application in precision medicine.
• Future research should focus on refining AGDA strategies for enhanced imaging and therapeutic efficacy.