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Cellular transformers for targeted therapy.

Chen Chen1, Yuqi Zhang2, Zhaowei Chen3

  • 1Institute of Food Safety and Environment Monitoring, and MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University, Fuzhou 350108, PR China.

Advanced Drug Delivery Reviews
|November 5, 2021
PubMed
Summary
This summary is machine-generated.

Natural cells are emerging as advanced drug carriers, leveraging their dynamic transformations for targeted therapy. This approach utilizes cellular changes beyond just surface display for enhanced drug delivery systems.

Keywords:
BioconjugationCell communicationCell therapyDrug deliveryTransformation

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Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Drug Delivery Systems

Background:

  • Natural cells offer biocompatibility and inherent dynamic properties for drug delivery.
  • Early applications focused on static cellular structures and surface proteins.
  • Recent advancements emphasize dynamic cellular changes for sophisticated delivery systems.

Purpose of the Study:

  • To review the dynamic cellular transformation behaviors utilized in targeted therapy.
  • To highlight the shift from static cell properties to dynamic cellular processes in drug delivery.
  • To explore novel functional aspects of cells beyond cargo delivery.

Main Methods:

  • Review of recent literature on cellular transformation in drug delivery.
  • Analysis of dynamic cellular behaviors including morphological and phenotypic changes.
  • Examination of cell-cell and cell-environment interactions for therapeutic applications.

Main Results:

  • Dynamic cellular behaviors like deformation, vesicle release, and polarization enhance targeted therapy.
  • Cells can locally produce therapeutics and hybridize with synthetic materials.
  • Cells provide functional handles for information exchange and communication in delivery systems.

Conclusions:

  • Dynamic cellular transformations represent a significant advancement in drug delivery systems.
  • Harnessing cellular dynamics offers novel strategies for targeted therapy and therapeutic applications.
  • Future research should explore the full potential of cellular communication and environmental interactions.