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Assessment of Kidney Function in Mouse Models of Glomerular Disease
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Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

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Obesity-Related Glomerulopathy: From Mechanism to Therapeutic Target

Lifang Wei1, Ye Li2, Yue Yu1

  • 1Department of Nephrology, The Third People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, People's Republic of China.

Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy
|November 5, 2021
PubMed

Insights

Obesity-related glomerulopathy (ORG) is a growing cause of kidney disease. Research highlights the inflammasome

Area of Science:

  • Nephrology
  • Immunology
  • Pathophysiology

Background:

  • Obesity-related glomerulopathy (ORG) is a secondary kidney disease driven by obesity, presenting with proteinuria and enlarged glomeruli.
  • The rising global obesity rates are altering kidney disease demographics, making ORG a significant contributor to end-stage renal disease (ESRD) and imposing a substantial socioeconomic burden.
  • Understanding ORG's complex and unclear pathogenesis is crucial for developing effective interventions.

Purpose of the Study:

  • To review recent advances in understanding ORG pathogenesis, focusing on inflammation and inflammasome pathways.
  • To explore the role of inflammasomes in podocyte injury within the context of ORG.
  • To summarize potential therapeutic strategies targeting the inflammasome for ORG treatment.

Main Methods:

  • Literature review of recent research on ORG mechanisms.
  • Analysis of studies investigating hypoxia, immune inflammation, and pyroptosis in ORG.
  • Focus on the role of inflammasomes in podocyte damage.

Main Results:

  • Inflammation, particularly involving the inflammasome pathway, plays a critical role in podocyte injury in ORG.
  • Advances in understanding metabolic processes, hypoxia, and pyroptosis contribute to ORG pathogenesis insights.
  • The inflammasome is identified as a key player in the progression of podocyte damage in ORG.

Conclusions:

  • The inflammasome is implicated in podocyte damage contributing to Obesity-related glomerulopathy.
  • Targeting inflammasome pathways presents a promising therapeutic avenue for managing ORG.
  • Further research into inflammasome-targeted therapies is warranted for ORG intervention.
Keywords:
Chinese herbal medicinesNLRP3 inflammasomeORGobesitypodocyte

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