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Interrelationships Between Coating Uniformity and Efficiency in Pan Coating Processes.

Michael Choi1, Stuart C Porter2, Axel Meisen3

  • 1PCTS, Inc, 89, 2 Lyndell Rd., Lyndell, Pennsylvania, 19354, USA. michael.choi@particlecoating.com.

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Summary
This summary is machine-generated.

Optimizing tablet coating requires balancing coating efficiency and uniformity. Most factors improving one negatively impact the other, necessitating careful process and formulation design for better tablet coatings.

Keywords:
Coating efficiencyCoating uniformityFilm thicknessShape factorTablet coating

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Area of Science:

  • Pharmaceutical Technology
  • Chemical Engineering
  • Materials Science

Background:

  • Tablet coating is crucial for drug delivery, affecting stability, appearance, and release.
  • Achieving uniform coatings while maximizing efficiency in pan coating is a complex challenge.
  • Existing models for coating uniformity require further refinement to incorporate process variables.

Purpose of the Study:

  • To investigate the intricate relationships between tablet coating uniformity and coating efficiency in pan coater systems.
  • To model the factors influencing spray zone characteristics and integrate them into existing uniformity models.
  • To elucidate the impact of various process parameters and tablet properties on both coating efficiency and uniformity.

Main Methods:

  • Utilized one-dimensional deposition analysis to model spray droplet behavior and spray zone size.
  • Integrated the spray zone model into an established analytical model for coating uniformity.
  • Analyzed the effects of numerous variables including tablet shape/size, process parameters, and solution properties.

Main Results:

  • Demonstrated an inverse relationship between coating efficiency and uniformity for most variables, excluding pan diameter and atomizing air flow rate.
  • Identified specific process parameters that enhance coating efficiency at the expense of uniformity, and vice versa.
  • Quantified the influence of tablet characteristics like shape and bed porosity on coating outcomes.

Conclusions:

  • Process optimization for tablet coating involves trade-offs between efficiency and uniformity.
  • Understanding these relationships is key to improving formulation, process design, and equipment selection.
  • Further research can leverage these findings for enhanced tablet coating performance and drug product quality.