A Review on Modular Peptide Anchoring Strategies for Functionalizing Liposomal Nanocarriers: Advancing Non-covalent...

Area of Science:

• Nanomedicine
• Drug Delivery Systems
• Cancer Therapeutics

Background:

• Liposomes are versatile drug carriers for targeted cancer therapy.
• Conventional liposome functionalization uses covalent ligand attachment, which can be complex and impact ligand activity.
• Non-covalent peptide insertion presents a simpler, adaptable alternative for liposome modification.

Purpose of the Study:

• To review non-covalent peptide-liposome interactions for targeted drug delivery.
• To analyze mechanisms, incorporation techniques, and therapeutic applications.
• To provide formulation guidance for stability, manufacturability, and clinical translation.

Main Methods:

• Focus on non-covalent peptide insertion into liposomal membranes.
• Analysis of hydrophobic and electrostatic interaction mechanisms.
• Evaluation of formulation-relevant criteria and comparative strategies.

Main Results:

• Non-covalent methods offer advantages in simplicity and adaptability over covalent approaches.
• Key formulation criteria include stability, manufacturability, and clinical translatability.
• Manufacturing, quality control, and regulatory aspects are critical for clinical success.

Conclusions:

• Non-covalent peptide-liposome interactions are a promising strategy for advanced drug delivery systems.
• This review offers decision frameworks for optimizing liposome formulation for cancer therapy.
• Addressing manufacturing and regulatory challenges is essential for clinical translation.