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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Development of a Curcumin-Loaded Hyaluronic Acid Nanogel Formulation Using Wet Granulation Method for Enhanced

Natkhanang Mookkie Boonpetcharat1, May Thu Thu Kyaw1, Veerakiet Boonkanokwong1

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Summary

This study developed novel granule formulations using poly(N-isopropylacrylamide)-grafted hyaluronic acid (HA-g-pNIPAM) to improve curcumin

Keywords:
curcumindelivery systemhyaluronic acid derivativeoral administration

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Curcumin exhibits significant antioxidant, anti-inflammatory, and anti-tumor properties.
  • Limited oral bioavailability due to poor solubility, instability, and rapid degradation hinders curcumin's therapeutic use.

Purpose of the Study:

  • To enhance curcumin's dissolution and stability using poly(N-isopropylacrylamide)-grafted hyaluronic acid (HA-g-pNIPAM) formulations.
  • To develop and characterize granule formulations for improved curcumin delivery.

Main Methods:

  • Three formulations were prepared: physical mixture (F10), encapsulated (F10 Encap), and control granules (F11).
  • Stability, flowability, particle size distribution, and drug release profiles were evaluated.
  • Curcumin content was assessed over 30 days under specific temperature and humidity conditions.

Main Results:

  • F10 Encap demonstrated superior curcumin stability, retaining ~94% content compared to F11 (~70%) after 30 days.
  • All formulations exhibited excellent flowability and consistent particle size distribution (150-180 μm).
  • Sustained curcumin release over 240 minutes was observed for F10 Encap and F10, indicating controlled release.

Conclusions:

  • HA-g-pNIPAM significantly improved curcumin's dissolution and stability.
  • Encapsulation within HA-g-pNIPAM offers a promising strategy for enhancing curcumin's oral bioavailability and therapeutic potential.