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The Impact of Surfactant Structures and High-Speed Mixing Dynamics in Achieving Nano-Sized Emulsions with Simple
Sakdinon Na Nan1, Jittima Amie Luckanagul1,2,3, Vipaporn Rakkanka Panapisal1
1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
Nanotechnology, Science and Applications
|December 27, 2024
Summary
This study optimized nanoemulsion production using high-speed homogenization for enhanced transdermal delivery. Precise control over mixing parameters and surfactant selection is key for stable nanoemulsions in cosmetic and pharmaceutical applications.
Area of Science:
- Colloid and Surface Science
- Materials Science
- Pharmaceutical Technology
Background:
- Nanoemulsions offer significant potential for enhancing transdermal drug delivery.
- Their stability and physical characteristics are crucial for effective application in pharmaceutical and cosmetic industries.
Purpose of the Study:
- To investigate the impact of mixing parameters and surfactant combinations on nanoemulsion properties.
- To evaluate nanoemulsions for transdermal drug delivery applications.
Main Methods:
- Utilized a standard high-speed homogenizer with various Polysorbate (Tween®) and Sorbitan ester (Span®) surfactant combinations.
- Assessed particle size, size distribution, Oswald ripening, and creaming index under single and intermittent processing.
Main Results:
- Synthesized nanoemulsions with particle sizes under 200 nm and uniform size distribution (PDI 0.3-0.5).
- Extended mixing times reduced droplet size and creaming; processing method had minimal impact.
- Demonstrated negligible Oswald ripening, indicating excellent long-term droplet size stability.
Conclusions:
- Optimal mixing parameters and surfactant selection are more critical than processing type for stable nanoemulsions.
- High-speed homogenization offers a cost-effective method for large-scale, stable nanoemulsion production for industry.
