The role of TNFTNFα/p53 pathway in endometrial cancer mouse model administered with apple seed extract
1Institute of Genetic Engineering, Hankyong National University, Jungang-ro, Anseong Gyeonggi-do, South Korea. ohmyfamily@naver.com.
Abstract:
Recent studies regarding the ability to relieve and reconstitute the endometrium in the treatment of endometrial cancer are limited. In this study, to analyze endometrial cancer, early endometrial cancer was induced by injecting a colon cancer cell line into the lower abdominal cavity of mice. Subsequently, the apple seed extract was administered orally to determine if the extract could affect the endometrial cancer. Administration of apple seed extract to the endometrial cancer model confirmed that the apoptosis suppressing mechanism was downregulated concurrently with the reduced expression of NF-κB. In contrast, the TNFα/p53 pathway upregulated the apoptosis. A number of clinical inferences could be derived from the results of this study; moreover, the administration of apple seed extract in a cancer metastasis model has not been reported in earlier toxicity induction studies. The results of this study indicated that the apple seed extract partially enhances apoptosis and the immune function related factors in endometrial cells. By improving tissue remodeling, the extract may help to restore the endometrium.
Insights
Apple seed extract may help treat endometrial cancer by promoting apoptosis and boosting immune function. This natural compound shows potential for restoring uterine tissue after cancer treatment.
Area of Science:
- Oncology
- Pharmacology
- Cell Biology
Background:
- Limited research exists on endometrial reconstitution post-endometrial cancer treatment.
- Understanding natural compounds' effects on endometrial cancer is crucial for novel therapeutic strategies.
Purpose of the Study:
- To investigate the potential of apple seed extract in treating early endometrial cancer.
- To analyze the molecular mechanisms by which apple seed extract affects endometrial cancer cells and tissue.
Main Methods:
- An early endometrial cancer model was established in mice by injecting a colon cancer cell line.
- Apple seed extract was administered orally to the induced cancer model.
- Changes in apoptosis-related pathways, including NF-κB and TNFα/p53, were analyzed.
Main Results:
- Apple seed extract downregulated the apoptosis-suppressing mechanism and reduced NF-κB expression.
- The TNFα/p53 pathway was upregulated, leading to increased apoptosis.
- The extract demonstrated partial enhancement of apoptosis and immune factors in endometrial cells.
Conclusions:
- Apple seed extract shows potential as a therapeutic agent for endometrial cancer.
- The extract may restore the endometrium by improving tissue remodeling and enhancing cellular apoptosis and immune functions.
