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Influence of maternal vomiting during early pregnancy on school-age respiratory health

Sunayna D Poeran-Bahadoer1, Evelien R van Meel1,2, Romy Gaillard1,3

  • 1The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Pediatric Pulmonology
|November 5, 2021
PubMed

Insights

Maternal daily vomiting in early pregnancy was linked to increased childhood wheezing and asthma risk. However, these associations were fully explained by sociodemographic factors, not the vomiting itself.

Area of Science:

  • Reproductive Health
  • Pediatric Respiratory Medicine
  • Epidemiology

Background:

  • Hyperemesis gravidarum (severe nausea and vomiting in pregnancy) may impact maternal nutrition and offspring respiratory health.
  • The specific effects of common vomiting symptoms during pregnancy on a child's respiratory health remain unclear.

Purpose of the Study:

  • To investigate the association between maternal daily vomiting in early pregnancy and respiratory outcomes in children at age 10.
  • To identify potential factors that may explain these observed associations.

Main Methods:

  • Prospective cohort study of 4232 mothers and their children.
  • Maternal vomiting assessed via questionnaire in early pregnancy.
  • Childhood respiratory outcomes (wheezing, asthma, lung function) evaluated at age 10 using questionnaires and spirometry.

Main Results:

  • Maternal daily vomiting was associated with higher forced expiratory flow (FEF75) and increased risk of current wheezing and ever asthma in children.
  • These associations were entirely explained by sociodemographic factors.
  • No significant associations were found with forced expiratory volume in 1s (FEV1), forced vital capacity (FVC), or the FEV1/FVC ratio.

Conclusions:

  • Sociodemographic factors fully account for the link between maternal daily vomiting in early pregnancy and childhood respiratory outcomes.
  • The direct impact of vomiting symptoms on offspring respiratory health appears to be mediated by socioeconomic circumstances.
Abstract

Keywords:
asthmachildhoodhyperemesis gravidarumvomitingwheezing

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