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t(14;18) Translocations in Dioxin-Exposed Workers
Daniel Hryhorczuk1, Irina Dardynskaia, Carsten Hirt
1Division of Environmental and Occupational Health Sciences, University of Illinois at Chicago School of Public Health, Chicago, Illinois (Dr Hryhorczuk, Dr Dardynskaia); Center for Global Health, University of Illinois College of Medicine, Chicago, Illinois (Dr Hryhorczuk, Dr Dardynskiy); Department of Internal Medicine C, Hematology and Oncology, Greifswald University, Greifswald, Germany (Dr Hirt); Environmental and Earth Sciences, Exponent, Atlanta, Georgia (Mr Turner); City of Chicago Department of Public Health, Chicago, Illinois (Dr Ruestow); Program in Public Health, University of California at Irvine, Irvine, California (Dr Bartell); Rollins School of Public Health, Emory University, Atlanta, Georgia (Dr Steenland); Institute of Pediatrics, Obstetrics and Gynecology, Kyiv, Ukraine (Dr Zvinchuk); Columbia University Mailman School of Public Health, New York, New York (Dr Baccarelli).
Objective:
To determine if occupational exposure to dioxins is associated with an increased frequency of t(14;18) translocations.
Methods:
A cross-sectional analysis of serum dioxin levels and t(14;18) frequencies in peripheral blood mononuclear cells in 218 former chemical plant workers and 150 population controls.
Results:
The workers had significantly higher geometric mean serum levels of 2,3,7,8-TCDD (26.2 vs 2.5 ppt) and TEQ (73.8 vs 17.7 ppt) than controls. There were no significant differences in the prevalence or frequency of t(14;18) translocations in the workers compared to controls. Among former workers with current or past chloracne who were t(14;18) positive, the frequency of translocations significantly increased with quartiles of 2,3,7,8-TCDD and TEQ.
Conclusion:
Chloracne appears to modulate the association between dioxin exposure and increased frequency of t(14;18) translocations.
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