Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Oct 14, 2025

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
08:20

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Published on: July 12, 2018

13.3K

Distraction enterogenesis in the murine colon.

Katherine I Portelli1, Anne-Laure Thomas1, Lauren S Wood1

  • 1Department of Surgery, Stanford University, Stanford, CA, United States.

Journal of Pediatric Surgery
|November 6, 2021
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Repeated lengthening using distraction enterogenesis: A porcine model.

Surgery·2026
Same author

A national database study of adjuvant steroids following Kasai portoenterostomy for biliary atresia.

Pediatric surgery international·2026
Same author

Unplanned conversion to open in elective laparoscopic and robotic paraesophageal hernia repair: a propensity score matched analysis of the ACS-NSQIP registry.

Surgical endoscopy·2026
Same author

Colonic dilation is associated with increased central line associated blood stream infection for patients with intestinal failure.

Intestinal Failure (New York, N.Y.)·2026
Same author

Epithelial ion transport in spring-lengthened jejunum in a porcine model.

Journal of pediatric surgery·2025
Same author

Influence of Sacral and Thoracolumbar Spinal Nerve Electrical Stimulation on Colonic Motility in Anesthetized Yucatan Male Pigs.

Neurogastroenterology and motility·2025

Biocompatible springs successfully lengthened mouse colons by 150% in a novel study. This distraction enterogenesis technique shows promise for treating pediatric intestinal diseases.

Area of Science:

  • Gastroenterology
  • Biomedical Engineering
  • Surgical Innovation

Background:

  • Distraction enterogenesis using intraluminal springs has effectively lengthened small intestine segments in mice.
  • The potential application of this technology to large intestinal lengthening remained unexplored.

Purpose of the Study:

  • To investigate the efficacy of biocompatible springs in lengthening murine large intestine segments.
  • To establish proof of concept for applying distraction enterogenesis to the colon.

Main Methods:

  • Nitinol spring-loaded capsules were surgically implanted into the cecum of C57BL/6 mice.
  • Cecal segment lengths were measured at implantation, 7 days, and 14 days post-implantation.
  • Histological analysis evaluated tissue adaptations, focusing on muscularis layer thickness.
Keywords:
Colonic lengtheningDistraction enterogenesisEndoluminal deviceIntestinal failure (IF)Short bowel syndrome (SBS)

More Related Videos

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
06:31

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Published on: June 2, 2023

1.2K
Murine Colitis Modeling using Dextran Sulfate Sodium DSS
08:39

Murine Colitis Modeling using Dextran Sulfate Sodium DSS

Published on: January 19, 2010

50.3K

Related Experiment Videos

Last Updated: Oct 14, 2025

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
08:20

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Published on: July 12, 2018

13.3K
Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
06:31

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Published on: June 2, 2023

1.2K
Murine Colitis Modeling using Dextran Sulfate Sodium DSS
08:39

Murine Colitis Modeling using Dextran Sulfate Sodium DSS

Published on: January 19, 2010

50.3K

Main Results:

  • Compressed springs in the cecum induced an average 150% lengthening of the colonic segments.
  • This lengthening was significantly greater than in control groups (empty or uncompressed springs).
  • The muscularis layers showed a trend toward increased thickness in the compressed spring groups.

Conclusions:

  • Compressed nitinol springs significantly lengthen the cecum in a mouse model, demonstrating feasibility.
  • Distraction enterogenesis technology can be applied to large intestinal models.
  • This approach holds promise for clinical applications in pediatric intestinal disease treatment.