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Self-healing polysaccharide-based injectable hydrogels with antibacterial activity for wound healing
Bing-De Zheng1, Jing Ye1, Yu-Cheng Yang1
1College of Chemical Engineering, Huaqiao University, Xiamen 361021, China; Xiamen Engineering and Technological Research Center for Comprehensive Utilization of Marine Biological Resources, Xiamen 361021, China.
Carbohydrate Polymers
|November 7, 2021
Summary
This review explores polysaccharide-based injectable hydrogels for wound healing. These advanced materials promote healing and combat bacterial infections, offering a promising solution for complex wound management.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Nanotechnology
Background:
- Chronic wounds present significant clinical challenges due to persistent bacterial infections and impaired healing.
- Effective wound management requires strategies that promote tissue regeneration and concurrently inhibit microbial proliferation.
Purpose of the Study:
- To review the preparation and properties of polysaccharide-based injectable hydrogels.
- To discuss the application of these hydrogels in antibacterial therapy for wound healing.
Main Methods:
- Literature review focusing on recent advancements in polysaccharide hydrogel synthesis.
- Analysis of hydrogel properties including injectability, self-healing, and moisture retention.
- Evaluation of antibacterial efficacy and wound healing promotion.
Main Results:
- Polysaccharide-based hydrogels demonstrate excellent injectability and self-healing capabilities under physiological conditions.
- These hydrogels effectively maintain a moist wound environment, crucial for accelerated healing.
- Incorporation of antibacterial agents or inherent hydrogel properties significantly inhibit bacterial growth.
Conclusions:
- Polysaccharide-based injectable hydrogels are highly promising for treating complex wounds.
- Their dual functionality in promoting healing and providing antibacterial action makes them valuable therapeutic agents.
- Further research into these hydrogels can lead to improved wound care strategies.
