Protein/polysaccharide-based hydrogels loaded probiotic-mediated therapeutic systems: A review

Area of Science:

• Biomaterials Science
• Drug Delivery Systems
• Microbiology

Background:

• Protein/polysaccharide hydrogels are investigated as drug delivery platforms.
• Probiotics are gaining attention for their health benefits and therapeutic potential.
• Combining hydrogels with probiotics offers a novel approach for disease treatment.

Purpose of the Study:

• To review the design strategies for hydrogel-based probiotic delivery systems.
• To explore the therapeutic applications of these systems in preclinical models.
• To identify current challenges in the development of these advanced therapies.

Main Methods:

• Literature review of hydrogel-based probiotic delivery systems.
• Analysis of studies demonstrating therapeutic effects in laboratory settings.
• Discussion of design considerations and future research directions.

Main Results:

• Hydrogels can effectively encapsulate and deliver probiotics.
• Probiotic-loaded hydrogels show potential in promoting wound healing.
• These systems demonstrate efficacy in improving intestinal and vaginal health in preclinical studies.

Conclusions:

• Hydrogel-encapsulated probiotics represent a promising strategy for targeted drug delivery.
• Further research is needed to overcome design challenges and translate these findings to clinical applications.
• This approach holds potential for treating a range of diseases by leveraging the benefits of probiotics.