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The integrated stress response in ischemic diseases.
Guangyu Zhang1, Xiaoding Wang1, Beverly A Rothermel1
1Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390-8573, USA.
Cell Death and Differentiation
|November 7, 2021
Summary
The integrated stress response (ISR) is activated by ischemic diseases like heart attack and stroke. Modulating the ISR offers a promising therapeutic target for improving outcomes in various ischemic conditions.
Area of Science:
- Biochemistry
- Cellular Biology
- Pathology
Background:
- Ischemic diseases, including myocardial infarction and stroke, are leading causes of death and disability.
- Pathological changes in ischemia, such as oxidative stress and inflammation, strongly induce the integrated stress response (ISR).
Purpose of the Study:
- To review the regulation of the ISR in response to ischemia.
- To summarize recent findings on the ISR's role in ischemic diseases.
- To discuss therapeutic strategies targeting the ISR for ischemic conditions.
Main Methods:
- Review of existing literature on ISR signaling pathways.
- Analysis of genetic and pharmacological evidence for ISR involvement in ischemic disease.
- Discussion of therapeutic opportunities based on ISR modulation.
Main Results:
- The ISR is significantly induced in various ischemic diseases.
- ISR signaling plays critical roles in the initiation and progression of ischemic conditions.
- Modulating the ISR shows potential for treating ischemic heart, brain, liver, and kidney diseases.
Conclusions:
- The ISR is a key cellular response to ischemic stress.
- Targeting the ISR presents a promising therapeutic avenue for ischemic diseases.
- Further research into ISR modulation could improve clinical outcomes for patients with ischemic conditions.
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