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Updated: Oct 14, 2025

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
Published on: August 14, 2019
OUR EXPERIENCE WITH CONTRAST-ENHANCED VOIDING UROSONOGRAPHY
Karla Rubelj1, Lea Oletić1, Bernardica Valent Morić1
1Department of Pediatrics, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia.
Insights
Vesicoureteral reflux (VUR) affects nearly 40% of children, with Grade II being most common. Early diagnosis using contrast-enhanced voiding urosonography (ceVUS) is crucial for effective treatment strategies.
Area of Science:
- Pediatric Urology
- Diagnostic Imaging
- Medical Diagnostics
Background:
- Vesicoureteral reflux (VUR) is a frequent congenital anomaly in the pediatric urinary system.
- Contrast-enhanced voiding urosonography (ceVUS) is a leading diagnostic tool for VUR.
- Understanding VUR characteristics and grading is essential for patient management.
Purpose of the Study:
- To compare VUR-associated imaging characteristics.
- To categorize pediatric VUR patients by reflux grade.
- To identify factors influencing VUR occurrence and severity.
Main Methods:
- Retrospective analysis of 183 pediatric patients.
- Utilized contrast-enhanced voiding urosonography (ceVUS) for VUR diagnosis.
- Categorized patients based on VUR grade and clinical data.
Main Results:
- VUR detected in 38.9% of children, mean age 1.7 years.
- Grade II VUR (60.3%) was most prevalent, followed by Grade III (29.4%).
- VUR correlated with recurrent UTIs; severe VUR more common in boys, moderate in girls.
Conclusions:
- VUR incidence was 28.6% in prenatal hydronephrosis cases.
- VUR occurrence was independent of age, gender, or UTI severity.
- Recommended ceVUS integration into Croatian UTI treatment algorithms for pediatric VUR diagnosis.
Abstract:
Vesicoureteral reflux (VUR) is one of the most common anomalies of the urinary system in children. Contrast-enhanced voiding urosonography (ceVUS) is one of the best methods in VUR diagnosis. This study compared characteristics associated with VUR specific images and categorized patients according to a particular VUR grade. The study included 183 children. VUR was detected in 38.9% of patients, mean age 1.7±1.1 years. Grade II VUR was most common (60.3%), followed by grade III (29.4%). Study results showed that VUR occurred irrespective of age, gender, previous ultrasound findings, causative agent, and severity of urinary tract infection (UTI). VUR was more common in children with recurrent UTI. In the group of children with the first UTI not caused by Escherichia coli or with recurrent UTI, boys more commonly suffered from severe VUR (grade IV-V; 66.7%), while girls suffered from moderate VUR (grade II-III; 100%). In this study, the incidence of VUR in prenatally diagnosed hydronephrosis was 28.6%. It is necessary to develop an algorithm for the treatment of children after UTI in Croatia, which should include ceVUS. All children with possible VUR should be referred to a specialized center where it is possible to perform ceVUS.
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