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Effective Management Of Topical Nosocomial Aspergillus Spp. Infections In Three Severely Burned Patients
O Pantet1, A Laurent1, P Abdel-Sayed1
1Lausanne University Hospital, University of Lausanne, Switzerland.
Annals of Burns and Fire Disasters
|November 8, 2021
Summary
Voriconazole effectively treated superficial Aspergillus infections in burn patients. However, hepatotoxicity led to discontinuation in some cases, necessitating alternative treatments like terbinafine cream.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Burn Care
Background:
- Nosocomial Aspergillus spp. infections pose significant risks for immunocompromised burn patients.
- Voriconazole (VRC) is a key antifungal for systemic infections, but its role in burn wound Aspergillus infections is less defined.
Purpose of the Study:
- To evaluate the efficacy and role of voriconazole in treating superficial Aspergillus spp. infections in severely burned patients.
- To assess voriconazole as a treatment option within burn center protocols.
Main Methods:
- Retrospective evaluation of voriconazole treatment in three severely burned patients.
- Analysis of treatment outcomes, including infection control and adverse events.
Main Results:
- Voriconazole achieved control and cure of superficial nosocomial Aspergillus spp. infections.
- Hepatotoxicity necessitated VRC discontinuation in two patients.
- Terbinafine cream was used adjunctively in two cases to manage infections.
Conclusions:
- Voriconazole is an effective antifungal for superficial Aspergillus infections in burn wounds.
- It presents a viable alternative to amphotericin B.
- Careful monitoring for hepatotoxicity is crucial during VRC treatment.
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