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Historical view on ergot alkaloids.

A Hofmann

    Pharmacology
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Ergot, once a poison causing epidemics, is now a vital source of pharmaceutical alkaloids. Its historical transformation highlights significant advancements in medicine and drug discovery.

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    Area of Science:

    • Pharmacology
    • Medical History
    • Organic Chemistry

    Background:

    • Ergot, historically a source of potent alkaloids, has transitioned from a feared pathogen to a valuable pharmaceutical resource.
    • The historical context of ergotism epidemics underscores the critical need for understanding and controlling ergot's effects.

    Observation:

    • Medieval ergotism epidemics caused widespread mortality.
    • Early documented use of ergot by midwives dates back to 1582.
    • Key ergot alkaloids like ergotoxine (1906), ergotamine (1918), and ergonovine (1935) were isolated and characterized.

    Findings:

    • The isolation of ergotamine provided the first chemically pure ergot alkaloid for therapeutic use.
    • Discovery of ergonovine identified a specific oxytocic principle, crucial in obstetrics.

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  • Subsequent research led to the synthesis and development of numerous valuable ergot-derived therapeutics.

    • Implications:

    • The study of ergot alkaloids has profoundly impacted obstetrics and internal medicine.
    • Continued research into ergot's chemistry and pharmacology yields novel therapeutic agents.
    • Understanding ergot's history provides context for modern pharmaceutical development and drug safety.