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A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

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Aptamer-based biosensors and application in tumor theranostics.

Tong Mo¹, Xiyu Liu¹, Yiqun Luo¹

¹National Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-targeting Theranostics, Guangxi Medical University, Nanning, China.

|November 8, 2021

Summary

Aptamer-based biosensors offer a promising alternative for tumor diagnosis, leveraging high specificity and low cost. This review highlights their advances in non-invasive imaging, treatment, and monitoring.

Keywords:

colorimetric aptasensor electrochemical aptasensor fluorescent aptasensor tumor diagnosis tumor marker

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Area of Science:

Biomedical Engineering
Molecular Diagnostics
Nanotechnology

Background:

Aptamers are oligonucleotide molecules with high specificity for target analytes.
Their advantages include low cost, high specificity, and good biocompatibility, making them suitable for biosensing applications.
Traditional tumor diagnosis methods can be invasive and costly.

Purpose of the Study:

To review recent advances in aptamer-based biosensors for tumor diagnosis.
To compare aptamer sensors with enzyme and immune sensors.
To evaluate the prospective advantages of aptamer-based biosensors in tumor theranostics and monitoring.

Main Methods:

Review of sensing designs and mechanisms based on aptamers.
Analysis of signal transduction modes: electrochemistry, colorimetry, and fluorescence.
Summary of applications in non-invasive tumor imaging and treatment.

Main Results:

Aptamer-based biosensors demonstrate significant potential in tumor diagnosis.
Various analytical methods utilizing aptamers have been developed.
These biosensors offer advantages over traditional diagnostic tools.

Conclusions:

Aptamer-based biosensors are a powerful tool for tumor diagnosis and theranostics.
Further research can enhance their application in clinical settings.
They hold promise for improved non-invasive tumor monitoring and treatment.