Intraoral hydrolysis of monofluorophosphate

The intraoral hydrolysis of monofluorophosphate (MFP) was compared in nine subjects with natural teeth and in nine edentulous subjects after a 1-min mouthrinse with a 100 ppm MFP solution. Analyses of total F and F- in whole saliva samples collected up to 15 min after the rinse suggested that apatite catalyzed breakdown of MFP mediated by dental enamel contributes significantly to the intraoral hydrolysis of MFP.